The Best Nitric Oxide Supplements (2021 Reviews)


Why would you want to take a nitric oxide supplement? To understand the benefits, you should first understand what nitric oxide is and the role it plays in the body. Enzymes in your body break down arginine, an amino acid, producing a gas, nitric oxide (NO), which is used for communication between cells. Arginine is found naturally in foods such as spinach, turkey (white meat), shrimp, crab, and sesame seeds. Nitric oxide actually plays a role in a variety of processes, such as controlling blood circulation and regulating the activities of the brain, kidneys, liver, lungs, and other organs.

For workout purposes, NO is involved in the release of hormones and adrenaline. Thanks to its effects on blood circulation, it’s believed to help with blood flow during and after workouts, delivering more nutrients to your muscles which can aid in growth and recovery. Many people believe that NO helps them workout longer and harder and recover faster. It’s also said to increase the availability of energy and increase the utilization of glucose. All of these possible effects are beneficial to the athlete who wants to increase their endurance and speed recovery after their toughest workouts.

Nitric oxide supplements typically contain one or more forms of arginine, the amino acid that’s a precursor to nitric oxide in the body. The most popular form is arginine alpha-ketoglutarate. So, if you’re looking to ramp up your fitness and get more results by working out harder and longer and reducing recovery time, a nitric oxide supplement might be just what you’re looking for. To help you narrow your options, we’ve rounded up 25 top-rated NO supplements, based on ingredients, reviews, and other considerations. Our picks are listed below in alphabetical order. Ratings information is based on Amazon reviews and is current at the time of this writing.

Of course, as with any supplement, you should discuss taking a nitric oxide supplement with your healthcare provider to ensure that these supplements will not put your health at risk through side effects or by interacting with other medications and supplements you’re taking.

1. Zhou Nutrition Nitric Oxide Supplement

Current Rating: 4.6

Zhou Nutrition Nitric Oxide Supplement

Scientifically formulated to give you more energy, strength, and stamina during every workout, Zhou Nutrition Nitric Oxide Supplement helps you pump like a pro and maximize your results.

Key Features:

  • L-Arginine, AAKG, Citrulline Malate, and Beet Root ingredients
  • Funnels clean oxygen and nutrient-rich blood straight into your muscle cells
  • Accelerates production of nitric oxide and increases blood flow
  • Money-back guarantee


Current Rating: 4.2


A concentrated nitric oxide precursor, BSN NITRIX 2.0 contains 3 grams of citrulline and 4 grams of creatine, supporting muscle fullness, vascularity, and pumps.

Key Features:

  • 3 grams citrulline, an amino acid and NO precursor
  • 4 grams creatine
  • Con-Cret-reinforced
  • Take 3 tablets 2 times per day

3. BulkSupplements Pure L-Arginine a-Ketoglutarate (AAKG) Powder

Current Rating: 4.7

BulkSupplements Pure L-Arginine a-Ketoglutarate (AAKG) Powder

This clean and pure supplement contains 500 grams of L-Arginine a-Ktoglutarate (AAKG) powder. It offers an extended increase in nitric oxide levels, improving the delivery of nutrients to your muscles. You shouldn’t take this supplement for more than 80 continuous days without temporarily stopping supplementation.

Key Features:

  • No fillers
  • Factory-sealed foil zip pouch
  • Lab-tested for guaranteed purity
  • Extended increase in nitric oxide levels
  • Take 1 tsp up to 3 times per day on an empty stomach

4. Cellucor, C4 Original Pre Workout Powder

Current Rating: 3.6

Cellucor, C4 Original Pre Workout Powder

Cellucor is America’s #1-selling pre-workout. A pre-workout powder, C4 is a premium formula packed with ingredients that boost energy and performance.

Key Features:

  • 150 mg caffeine for energy
  • 1 gram creatine nitrate (NO3-T) for focus
  • 1.6 grams carnosyn beta-alanine for pumps
  • 1 gram arginine AKG for endurance
  • Comes on quickly and lasts longer compared to other supplements
  • Beta Alanine produces a tingly sensation throughout the body that lets you know it’s working

5. Cellucor, NO3 Chrome, Nitric Oxide Pump Amplifier

Current Rating: 3.7

Cellucor, NO3 Chrome, Nitric Oxide Pump Amplifier

If you love Cellucor’s products but are just looking for a pump amplifier, NO3 Chrome might be just what you need. It contains 83 mg Vitamin C, 10 mg Calcium, 1250 mg Arginine Nitrate, and 750 mg extreme vascularity blend for increased muscle blood flow and long-lasting pumps.

Key Features:

  • Reduces nitrate tolerance
  • Contains grape seed extract to reduce swelling caused by injury
  • Substantially increases NO levels
  • 30-day money-back guarantee

6. Evlution Nutrition Pump Mode Nitric Oxide Booster

Current Rating: 4.5

Evlution Nutrition Pump Mode Nitric Oxide Booster

To support intense pumps, performance, and vascularity, Evlution Nutrition Pump Mode Nitric Oxide Booster has your back. An unflavored powder, you can take it alone or add it to your pre-workout stack to amplify your results.

Key Features:

  • Caffeine-free, non-stimulant pump accelerator
  • Supports blood flow and oxygen transport
  • Vitamin C & D complex
  • Contains HYDROMAX, the next generation of glycerol

7. Force Factor VolcaNO Pre-Workout Nitric Oxide Booster with Creatine

Current Rating: 4.0

Force Factor VolcaNO Pre-Workout Nitric Oxide Booster with Creatine

Force Factor is the official sports nutrition brand of Bo Jackson. VocaNO is a nitric oxide booster delivering strength, lean muscle, and vascularity.

Key Features:

  • Contains the legendary nitric oxide booster L-citrulline
  • Contains a special form of creatine HCl called CON-CRĒT
  • Contains Agmatine, a powerful L-arginine byproduct
  • Topped off with an energy-boosting component

8. Healthy Body Nitric Oxide Pump Amplifier and Testo Booster Combo Pack

Current Rating: 3.4

Healthy Body Nitric Oxide Pump Amplifier and Testo Booster Combo Pack

If you’re looking to become better, faster, and stronger, Healthy Body’s Nitric Oxide Pump Amplifier and Testo Booster Combo Pack, formulated specifically for men, has everything you need to make it happen. A special combination of three of the most powerful NO boosters available, this extra-potent formula promises rapid results.

Key Features:

  • Great pre-workout supplement
  • Combines L-Arginine HCL, L-Arginine AKG, and Citrulline Malate
  • Made in the USA
  • 100% money-back guarantee

9. Jacked Factory NITROSURGE Pre Workout Supplement

Current Rating: 4.6

Jacked Factory NITROSURGE Pre Workout Supplement

A scientifically dosed, maximum-strength pre-workout supplement, Jacked Factory NITROSURGE provides everything you need for a next-level workout and next-level results.

Key Features:

  • Promotes fat burning and muscle building
  • Includes L-citrulline, betaine anhydrous, beta alanine, caffeine, and theanine
  • Boosts strength and fuels powerful muscle pumps
  • Cherry Limeade flavor
  • 100% money-back guarantee

10. KAGED MUSCLE – L-Citrulline Unflavored Powder

Current Rating: 4.5

KAGED MUSCLE – L-Citrulline Unflavored Powder

If you’re craving some massive, sleeve-splitting muscle pumps, KAGED MUSCLE’s L-Citrulline Powder will boost L-arginine and nitric oxide levels, delivering the nutrients your muscles need to get ripped.

Key Features:

  • Each serving contains 2 g of pure L-citrulline
  • No artificial flavors or colors
  • Hypoallergenic, vegetarian, and kosher
  • Third-party tested to be free of all banned substances
  • Proprietary manufacturing process

11. LMNITRIX VEINZ – Best Nitric Oxide Booster

Current Rating: 4.1

LMNITRIX VEINZ - Best Nitric Oxide Booster

This top muscle mass and pump supplement contains Yohimbe, L-Arginine, and L-Citrulline, and it’s scientifically proven to aid in increasing endurance while reducing recovery time.

Key Features:

  • Made in the USA in a GMP-certified, FDA-regulated facility
  • Niacin, Senforin, and Yohimbie combination dramatically increases blood flow
  • 60-day money-back guarantee

12. Muscle X Boost- Premium L-Arginine Formula

Current Rating: 4.6

Muscle X Boost- Premium L-Arginine Formula

This supplement contains scientifically validated, revolutionary beet root nitrates, as well as lovage powder and l-citrulline to fuel nitric oxide production.

Key Features:

  • Pre-workout amplifier
  • No jitters and no crash
  • Coenzyme Q-10 helps to feet ATP production
  • Works at the source of metabolic ignition

13. MuscleTech NaNOX9, Next Generation Pre Workout

Current Rating: 4.2

MuscleTech NaNOX9, Next Generation Pre Workout

NaNOX9 is scientifically studied for muscle performance. It increases blood flow to the muscles and has pronounced effects on muscle pumps, delivering more nutrients to your muscles for more effective training and faster recovery.

Key Features:

  • Extreme pumps, vascularity, and hardness
  • Increases blood flow to the muscles
  • Supports muscle building
  • Delivers the performance-booster beta-alanine and unique sensory effects
  • Rapidly increases NO production

14. Nordic Clinical Nitric Oxide BloodBoost

Current Rating: 3.7

Nordic Clinical’s Nitric Oxide BloodBooster

Nordic Clinical Nitric Oxide BloodBoost promotes a healthy blood flow with a single dose, decreasing your risk by improving blood flow and circulation. It’s the only formula to combine Setria® Glutathione and Spectra™ for advanced, fast-acting nitric oxide production.

Key Features:

  • Rapidly enhances blood flow to deliver oxygen and critical nutrients
  • Stimulates nitric oxide production
  • Supports endothelial health for cardiovascular function
  • Helps eliminate waste products that can result in fatigue

15. BioNox Nutrients M3 Miracle Molecule Max Nitric Oxide Nutrition Supplement

Current Rating: 4.5

BioNox Nutrients Nitric Oxide

A performance-boosting supplement for athletes, BioNox Nutrients M3 Miracle Molecule Max increases blood flow, oxygen, and nutrient delivery within the body thanks to an effective combination of clinically proven ingredients.

Key Features:

  • L-arginine, citrulline, beet powder, and Vitamins C, D, and E
  • Supports male fertility and increases libido
  • Medical doctor-certified
  • Made in the USA in FDA-approved and GMP-compliant labs
  • 90-day money-back guarantee

16. Nu-Life Supplements HEART 360

Current Rating: 4.6

Nu-Life Supplements HEART 360

Based on scientific research, supplements containing both L- Arginine and L-Citrulline yield greater results when combined with a good workout plan, and that’s exactly what you get with Nu-Life’s HEART 360.

Key Features:

  • L Arginine encourages nitric oxide production
  • Relaxes narrow blood vessels and increases oxygen and blood flow to the heart
  • Helps to lower blood pressure and increase energy levels
  • Boosts male performance
  • Strawberry-kiwi flavor
  • 30-day money-back guarantee

17. Old School Labs VINTAGE BLAST

Current Rating: 4.4


A natural pre-workout energy drink, Old School Labs Vintage Blast is the first two-stage pre-workout supplement. It’s designed to provide a steady delivery of ingredients to power you through workouts and competitive events.

Key Features:

  • Third-party tested
  • Made with premium ingredients
  • Non habit-forming product
  • Made in the USA
  • Money-back guarantee

18. Havasu Nutrition L-Arginine Nitric Oxide Booster Supplement for Muscle Growth, Vascularity & Energy

Current Rating: 4.4

Havasu Nutrition Nitric Oxide Booster

This supplement will help you build muscle mass thanks to L-Arginine, which is an essential amino acid that converts into Nitric Oxide and helps to promote healthy blood circulation.

Key Features:

  • Potent L-Arginine complex
  • Supports metabolism and endurance
  • 100% money back guarantee
  • Formulated in the US

19. Pure Encapsulations – Nitric Oxide Ultra

Current Rating: 4.3

Pure Encapsulations - Nitric Oxide Ultra

A unique blend of cranberry and grape seed extracts combined with citrulline to increase blood flow, Pure Encapsulations Nitric Oxide Ultra offers cardiovascular support and heavy flow-mediated dilation.

Key Features:

  • CranLoad™ for vascular support
  • Hypoallergenic and research-based
  • No wheat, gluten, egg, peanuts, coatings, or shellacs
  • No trans fats or hydrogenated oils
  • No artificial colors, flavors, or sweeteners
  • No unnecessary binders, fillers, or preservatives

20. Raw Nutrition Labs NutriBeet Nitric Oxide Optimizer

Current Rating: 4.2

Raw Nutrition Labs NutriBeet Nitric Oxide Optimizer

100% non-GMO and organic, Raw Nutrition Labs NutriBeet Nitric Oxide Optimizer has a high nitrate potency thanks to the company’s cutting-edge beetroot extraction methods and use of only the finest-quality beets.

Key Features:

  • Advanced blend of nitrate stimulating amino acids, electrolytes, Vitamin B6/B12, and BCAA 3:2:1 muscle recovery support
  • Infused with a delicious all-natural cherry sweetness
  • No artificial sweetener, colors, or fillers
  • Dissolves effortlessly in all liquids

21. Roam Nitric Oxide L-Arginine Supplement

Current Rating: 4.3

Roam Nutrition Nitric Oxide L-Arginine supplement

For muscle growth, libido enhancement, fat loss, stamina, and energy, look no further than Roam Nitric Oxide L-Arginine Supplement. This high-potency blend contains L-arginine (AAKG + HCI) coupled with L-Citrulline Malate for a boost to heart health and muscle growth while providing a natural energy boost.

Key Features:

  • 2 tablets per serving
  • Helps increase blood flow throughout the body
  • Aids in building muscles and burning fat
  • Boosts energy and fights fatigue
  • Made in the USA
  • Money-back guarantee

22. Sheer Strength Labs SHEER N.O. Nitric Oxide Supplement

Current Rating: 4.3

Sheer Strength Labs SHEER N.O. Nitric Oxide Supplement

SHEER N.O. Nitric Oxide Supplement is guaranteed to build muscle and strength when taken in conjunction with a solid workout plan. It increases workout performance to boost muscle pump and promotes heart health, too.

Key Features:

  • Increases blood flow from the heart to every area of the body
  • Fast muscle growth
  • Promotes a healthy heart
  • 30-day money-back guarantee

23. Six Star Pro Nutrition Elite Series Pre Workout N.O. Fury

Current Rating: 4.4

Six Star Pro Nutrition Elite Series Pre Workout N.O. Fury

Six Star Pro Nutrition Elite Series N.O. Fury is a pre-workout powder in a pill, designed to enhance nitric oxide production for better muscle pumps.

Key Features:

  • Delivers a precise dose of ultra-pure arginine
  • Scientifically-formulated pre-workout
  • 3 forms advanced l-arginine: l-arginine alpha-ketoglutarate and HCL plus l-citrulline
  • Elicits rapid vascular expansion

24. The Genius Brand Genius Pre Workout

Current Rating: 4.7

The Genius Brand Genius Pre Workout

Looking for a synergistic mind-to-muscle connection? The Genius Brand’s Genius Pre-Workout delivers just that. It’s the first clinically-dosed nootropic-based pre-workout, packed with key performance enhancers and several brain nutrients to create a true mind-to-muscle connection.

Key Features:

  • No caffeine
  • Clinical doses of key ingredients
  • Naturally sweetened with stevia
  • No fillers or “junk”
  • L-Citrulline, EleATP, and L-Arginine for rapid N.O. elevation & massive pumps
  • Grape Limeade flavor

25. 2Healthy Extra-Strength L-Arginine

Current Rating: N/A

2Healthy Extra-Strength L-Arginine

This supplement combines L Arginine with Arginine HCI, Arginine Alpha Ketoglutrate, and Citrulline, a precursor to nitric oxide production. The manufacturer says this supplement expands blood vessels for increased blood flow, allowing more oxygen to reach your muscles, brain, heart, lungs, and other organs.

Key Features:

  • Supports energy levels and lean muscle
  • Increases blood flow and relaxes arteries
  • 60-day money-back guarantee
  • Serving size: 2 capsules
  • Made in the USA at an FDA-registered facility under Good Manufacturing Practice (GMP) standards


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